Iodoacetamido-PEG6-acid is a aqueous soluble PEG linker containing a terminal carboxylic acid and Iodoacetamido group. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. HATU) to form a stable amide bond. The Iodoacetamido moiety is commonly used to bind covalently with the thiol group of cysteine so the protein cannot form disulfide bonds.
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