DBCO-Val-Cit-PAB-MMAE is a precursor of antibody drug conjugates (ADCs). It contains a protease-sensitive Val-Cit dipeptide, DBCO group, and a MMAE payload. DBCO group is a highly reactive cycloalkyne which is commonly used for copper-free Click Chemistry reactions. The MMAE is a synthetic antineoplastic agent. It can be attached to a monoclonal antibody (mAb) which directs it toward cancer cells.
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