Azide-Polysarcosine50 is a lipid-polypeptoid conjugate based on the endogenous amino acid sarcosine (N-methylated glycine) with an average of 50 sarcosine units. The azide can undergo copper-catalyzed Click Chemistry reactions with alkynes, DBCO and BCN. Polysarcosine has been shown to have a higher protein secretion with a reduced immunostimulatory response observed when compared to systems based on polyethylene glycol (PEG) lipids. Azide-Polysarcosine can be used to create lipids for the formation of lipid nanoparticles (LNPs) to be used in therapeutic applications of mRNA.
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