Bis-sulfone-PEG4-azide is a reagent featuring two sulfone groups and an azide group. The azide is a click chemistry handle which readily reacts with terminal alkynes or strained cyclooctynes to form triazole links with a target molecule. The sulfone group is a covalent ligand which is used to bind thiols via a Michael addition, and this can be employed to label cysteine residues in proteins. The presence of two leaving groups on this molecule allows this linker to bind two thiols at a time.
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