306Oi9-cis2 is a multi-ionizable aminolipid analog of 306Oi10 which features a central amine linked to two identical amine-branched side chains. Each side chain is linked to unsaturated hydrophobic tails via biodegradable ester bonds. Ionizable lipids are typically used in the design of nucleic acid lipid nanoparticles, as their pH-dependent positive charge stabilizes the anionic nucleic acids they encapsulate.
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