Thalidomide-NH-PEG2-COOH is a PROTAC linker featuring a thalidomide, a hydrophilic PEG spacer, and a carboxylic acid. Thalidomide is an E3 ligase activator, promoting the ubiquitinylation of a given protein. Meanwhile, the carboxylic acid may react with amines in the presence of coupling reagents.
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