4-[(8-Aminooctyl)oxy]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione is a PROTAC linker featuring a thalidomide, a hydrophilic PEG spacer, and a primary amine. Thalidomide is a ligand for E3 ligase, which ubiquitinylates proteins. Meanwhile, the amine may be used in a number of reactions such as amidations or reductive aminations, among many others.
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