Thalidomide-NH-PEG3-COOH is a PROTAC linker featuring a thalidomide, a hydrophilic PEG spacer, and a carboxylic acid. Thalidomide is a ligand for E3 ligase, which recruits proteins for proteolytic destruction. This structure features a carboxylic acid whcih may be used for further derivatization through reactions with amines or alcohols.
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