Thalidomide-PEG4-NH2, HCl salt4-[(7-Aminoheptyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione, HCl salt is a PROTAC linker featuring a thalidomide, a PEG spacer, and a primary amine. Thalidomide is a ligand for E3 ligase, which ubiquitinylates proteins for subsequent proteolysis. This structure's amine may be used for further derivatization through a variety of reactions.
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