CL4H6, an ionizable cationic amino lipid with an apparent pKa of 6.35, has been utilized in creating lipid nanoparticles (LNPs). LNPs incorporating CL4H6 and carrying siRNA for Factor VII reduction in mice's liver levels and tumor-targeting siRNAs for CD45, STAT3, and HIF-1alpha in OS-RC-2 renal cancer mouse xenograft models demonstrate tumor volume reduction. The pKa is 6.35.
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