Lipid AX4 serves as an ionizable lipid in lipid nanoparticles (LNPs) for in vivo mRNA delivery. These LNPs, containing SARS-CoV-2 Delta variant mRNA encoding the SARS-CoV-2 spike glycoprotein receptor-binding domain (RBD), induce the production of antibodies that specifically bind to the SARS-CoV-2 spike RBD.
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