Sulfo TCO-Maleimide is a water-soluble reagent for attaching TCO moieties to cysteine-containing peptides or other thiol-containing molecules. The maleimide group selectively reacts with reduced thiols at pH 6.5-7.5, forming stable thioether bonds. The hydrophilic sulfonated spacer enhances water solubility, and the short spacer arm adds minimal mass to the modified molecules. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries. The half-life of TCO is short as it will naturally isomerize into CCO (cis-cycloctene) and lose the reactivity. TCO compound is not recommended for long term storage.
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