DBCO-PEG-2-Val-Cit-PAB-PNP serves as a cleavable ADC linker derivative where PNP carbonate acts as a highly activated leaving group which may be used to react with amines. The Val-Cit dipeptide can be cleaved by Cathepsin B. The DBCO acts as a click chemistry handle that can react with azides without copper. Water solubility is enhanced via the PEG linker.
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