(E/Z)-4-Hydroxytamoxifen is an active metabolite of tamoxifen and a selective estrogen receptor modulator. It's integral to systems like TRAP/TRAP2, providing genetic access to neuron activity, and is employed in CRISPR/Cas9 gene editing to activate inactivated Cas9 nuclease. Additionally, it acts as an intramembranous lipid peroxidation inhibitor, scavenging peroxyl radicals.
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