Biotin-PEG12-Picolyl azide features an azide group for copper-catalyzed azide-alkyne cycloaddition (CuAAC) with linear alkyne-containing molecules, with the picoyl azide moiety increasing the efficiency and speed of the CuAAC reaction for improved biocompatible labeling. Compared with conventional azides, picolyl azide will allow to use at least 10-fold less copper catalyst to yield the same click reaction rate as regular azide, because picolyl moiety can chelate Cu to raise the effective concentration of Cu(I) at the reaction site.
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