Biotin-PEG12-Picolyl azide features an azide group for copper-catalyzed azide-alkyne cycloaddition (CuAAC) with linear alkyne-containing molecules, with the picoyl azide moiety increasing the efficiency and speed of the CuAAC reaction for improved biocompatible labeling. It can also participate in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups without a copper catalyst.
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