TOR-G4 is a thiazole orange derivative that acts as a fluorescent probe for visualizing G-quadruplexes (G4s), unique DNA and RNA secondary structures formed by four guanine bases. TOR-G4 enables G4 imaging through fluorescence lifetime changes upon binding, with its lifetime highest in the presence of G4s. Within cells, TOR-G4 primarily colocalizes with RNA in the cytoplasm and nucleoli, providing an antibody-free, FLIM-compatible tool to study RNA G4s and their functions in cellular processes.
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