Fmoc-PEG8-Val-Cit-PAB-PNP is a cleavable ADC linker engineered for antibody–drug conjugates. Its Val-Cit moiety is designed to be cleaved by cathepsin B, triggering payload release within target cells, while the PNP group acts as an excellent leaving group for conjugation with amine-bearing payloads. Additionally, the incorporated PEG12 units boost the compound's water solubility. The Fmoc group can be deprotected under basic conditions.
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