MC-Glu(OtBu)-Gly-Cit-PAB-PNP functions as a cleavable tripeptide linker, exhibiting exceptional stability in the bloodstream, resisting degradation and human neutrophil protease cleavage, while still enabling the intracellular release of payloads in a discrete, traceless drug-release manner. The linker contains glutamic acid, which is protected by a terminal t-butyl ester that can be deprotected under acidic conditions. Also, it consists of a maleimide moiety for cysteine conjugation as well as an amine-reactive PNP group, which is a great leaving group. Please contact us for GMP-grade inquiries.
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