Acid-PEG4-GGFG-DXD is a cleavable ADC linker-payload molecule applied in the creation of antibody-drug conjugates (ADCs). The carboxylic group reacts with primary amines via activators such as HATU. DXD, a derivative of Exatecan, is a novel DNA topoisomerase I inhibitor as an ADC payload. The PEG4 units improves the solubility of the compound in aqueous media.
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