Fruquintinib (HMPL-013) is a potent and selective VEGFR1/2/3 inhibitor (IC50s = 33, 0.35, and 35 nM, respectively). It also inhibits RET, FGFR1, and c-Kit at higher concentrations. Fruquintinib suppresses VEGF-induced endothelial cell proliferation and tube formation and reduces tumor growth in multiple xenograft models. Reagent grade, for research use only.
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