Fmoc-Val-Ala-PAB-PNP is a peptide cleavable ADC linker precursor employed in the synthesis of antibody-drug conjugates (ADCs). The Val-Ala will specifically be cleaved by Cathepsin B. The Fmoc group can be deprotected under basic conditions to obtain the free amine, which can be used for further conjugations. The PNP group can react with amine-bearing payloads and will function as a good leaving group. β-Glucuronide linkers are enzymatically cleavable linkers used in antibody-drug conjugates (ADCs). They are stable in circulation and release the cytotoxic payload upon cleavage by β-glucuronidase enzymes within tumor cells. Their hydrophilic nature reduces ADC aggregation, enhancing therapeutic efficacy.
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