Duocarmycin SA is an orally bioavailable antitumor antibiotic with picomolar potency (IC?? = 10 pM). It acts as an irreversible, sequence-selective DNA minor groove alkylator, inducing cytotoxicity through covalent DNA modification. Duocarmycin SA exhibits synergistic effects with proton radiation in glioblastoma multiforme (GBM) cells in vitro.
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