Ac-Arg-Gly-Lys(Ac)-AMC is a fluorogenic peptide substrate for histone deacetylase (HDAC) activity assays. HDAC-mediated deacetylation of the ε-acetyl-lysine is followed by trypsin cleavage, releasing the AMC fluorophore, enabling sensitive and quantitative measurement of HDAC enzymatic activity in biochemical screening assays.
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