NHS-PEG4-GGFG-DXD is a unique tetrapeptide linker-payload compound used for antibody-drug conjugates (ADCs). The NHS is reactive with amine moieties. DXD, a derivative of Exatecan, is a novel DNA topoisomerase I inhibitor as ADC payload. The PEG8 moiety boost the solubility of the compound in aqueous media, GGFG is protease cleavable peptide.
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