APN-PEG4-amine, HCl salt is a heterobifunctional PEG linker for antibody-drug conjugate (ADC) synthesis, featuring an APN moiety with high chemoselectivity for cysteine residues and a primary amine for downstream functionalization. The resulting APN–cysteine conjugates exhibit exceptional stability in aqueous media, plasma, and living cells, enabling precise and durable bioconjugation. The PEG4 units elevate the hydrophilicity of the molecule.
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