Azido-PEG8-Amido-Val-Lys(Boc)-PAB-OH is a cleavable linker used in antibody–drug conjugate (ADC) development, featuring an azide for strain-promoted click conjugation, a PEG8 spacer for enhanced water solubility, and a Val-Lys(Boc)–PAB (para-aminobenzyl) self-immolative motif. This design enables stable circulation, followed by intracellular enzymatic cleavage to efficiently release cytotoxic payloads. Ready to conjugate to a wide range of ADC payloads, it offers researchers a reliable and versatile tool for next-generation biologics, targeted therapeutics, and linker–payload optimization.
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