Azido-PEG8-Amido-Val-Lys-PAB-OH is a cleavable ADC linker with a free lysine amine for direct payload conjugation. The construct features an azide handle for copper-free click chemistry, a PEG8 spacer for enhanced aqueous solubility, and the Val-Lys–PAB self-immolative unit that undergoes efficient enzymatic cleavage inside target cells to release the active drug. Optimized for antibody–drug conjugate (ADC) payload attachment, this linker enables stable circulation, precise bioorthogonal coupling, and controlled intracellular release in targeted therapeutic applications.
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