Bromo-PEG12-acid represents a PEG linker with a bromide group and terminal carboxylic acid. The hydrophilic PEG spacer elevates solubility in aqueous media. The bromide (Br) is a good leaving group for nucleophilic substitution reactions. The carboxylic acid reacts with primary amine groups in the presence of activators such as EDC or HATU.
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