Mal-PEG12-Val-Cit-PAB-Exatecan represents a linker-payload that may be used in the production of antibody-drug conjugates. Val-Cit-PAB-Exatecan is an enzymatically cleavable peptide with an exatecan payload. The Val-Cit dipeptide will be specifically cleaved by Cathepsin B. The maleimide moiety can react with thiol-containing biomolecules. The PEG12 chain bolsters the molecule's hydrophilicity.
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