Azido-PEG4-Amido-Val-Cit-PAB-PNP represents a cleavable peptide ADC linker. The Val-Cit dipeptide can be cleaved by Cathepsin B. PNP group is a good leaving group when conjugating with amine-bearing payloads. The azido group will react with DBCO, BCN, or other alkyne groups through click chemistry. The PEG4 linker enhances aqueous solubility.
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