(2S)-3-amido-propanyl-amino-bis(m-PEG8)-2-maleimido-acid-(GGFG-Dxd) is a novel branched GGFG-Dxd linker-payload molecule designed to address several common shortcomings of conventional ADC designs, including poor physicochemical properties and linker-driven DAR instability. The maleimide moiety reacts with thiol groups on the antibody, while two PEG8 chains not only helps reduce aggregation, but also accelerate maleimide ring-opening hydrolysis to increase the conjugate stability. In addition, the two PEG chains improve aqueous solubility.
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