Antibody azido-PEG8-VC-PAB-Exatecan Conjugation Kit, 3 vial

This antibody azido-PEG8-VC-PAB-Exatecan Conjugation Kit is designed to conjugate 1 mg of antibody with the chemotherapeutic drug, Exatecan via copper-free click chemistry. The linker structure (shown below) is also composed of a cleavable val-cit dipeptide, which enhances drug molecule release to the cell. The Exatecan is a water-soluble, synthetic drug that's used to treat cancer. It is an antineoplastic agent that works by inhibiting DNA replication, stabilizing the complex between DNA and topoisomerase I, and triggering apoptosis. Exatecan has been studied as a single agent, as part of antibody-drug conjugates, and as a macromolecular conjugate.