Antibody MC-VC-PAB-Doxorubicin Conjugation Kit, 3 vial

This MC-VC-PAB-Doxorubicin Conjugation Kit is designed to conjugate 1 mg of antibody with the chemotherapeutic drug, Doxorubicin via standard malemide/thiol chemistry. The linker structure (shown below) is also composed of a cleavable val-cit dipeptide, which enhances drug molecule release to the cell. The Doxorubicin is a type of chemotherapy drug called an anthracycline. It slows or stops the growth of cancer cells by blocking an enzyme called topo isomerase 2. Cancer cells need this enzyme to divide and grow. Doxorubicin is in the anthracycline and antitumor antibiotic family of medications. It works in part by interfering with the function of DNA. The Doxorubicin is very toxic to use as a drug on its own, and induce serious side effects. So, it's usually delivery a drug delivery systems to reduce the toxicity, and also attached to a monoclonal antibody (mAb) that recognizes a specific marker on cancer cells. The mAb directs Doxorubicin to the cancer cells for specific kill the cancer cells. This product is used for research only.

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