Desmopressin Acetate trihydrate is a synthetic vasopressin analog with enhanced antidiuretic activity and minimal vasopressor effects. It selectively activates V2 receptors in renal collecting ducts, promoting aquaporin-2 translocation, increasing water reabsorption, and reducing urine output. With high V2R affinity (Ki ~0.3 nM) and low V1 activity, it is used clinically for central diabetes insipidus, nocturnal enuresis, and mild hemophilia A by elevating factor VIII and von Willebrand factor levels.
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