Dual payload linker is a class of advanced payload-linker molecules that carry two payloads-either identical or different (e.g., MMAE, Exatecan, or Doxorubicin)-attached via a single linker. This unique design enables the conjugation of two payloads to a single antibody in a one-step reaction. By allowing dual mechanisms of action, dual payload linkers can enhance drug potency, overcome drug resistance, and improve therapeutic efficacy against cancer.