Methyltetrazine-amido-N-bis(PEG4-NHS ester) is a click chemistry PEG reagent which contains two NHS ester groups and a methyltetrazine group. This reagent can react with TCO-containing compounds to form a stable covalent bond without the catalysis of Cu or elevated temperatures. The inverse-electron demand Diels-Alder cycloaddition reaction of TCO with tetrazines is the fastest bioorthogonal reaction with exceptional selectivity. The NHS esters can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The hydrophilic PEG linker increases the water solubility properties of the compound. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.
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