N4-Bz-5'-O-DMTr-2'-O-(2-methoxyethyl)-5-methylcytidine-3'-CED-phosphoramidite features a 2'-O-MOE group and can be incorporated into oligonucleotide phosphoramidites for antisense RNA. The 2'-MOE backbone enhances duplex stability, nuclease resistance, and has low toxicity.
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