2-(2,6-dioxopiperidin-3-yl)-4-({2-[2-(2-hydroxyethoxy)ethoxy]ethyl}amino)-2,3-dihydro-1H-isoindole-1,3-dione is a PROTAC linker featuring a thalidomide, a hydrophilic PEG spacer, and an alcohol. Thalidomide is an E3 ligase activator, promoting the proteolysis of a given protein. Meanwhile, the alcohol group is a versatile site for further derivitization.
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