2-(2,6-dioxo-3-piperidyl)-4-[2-(2-hydroxyethoxy)ethylamino]isoindoline-1,3-dione is a PROTAC linker featuring a pomalidomide, a hydrophilic PEG spacer, and an alcohol. Pomalidomide is an E3 Ligase activator, which promotes proteolysis of target proteins via ubiquitinylation. This structure features a hydroxy group which may be used for further derivatization.
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