TCO Phosphoramidite C6 acts as a versatile reagent for TCO-modified oligonucleotides, introducing a TCO moiety into substrates with primary or secondary hydroxyl groups. Trans-cyclooctene readily reacts with tetrazines via inverse electron-demand Diels-Alder cycloaddition (IEDDA). The resulting TCO-Tetrazine ligation offers ultrafast kinetics, selectivity, and long-term stability in aqueous media, making it valuable for low-concentration applications like protein-protein conjugations.
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