MC-Val-Cit-PAB-MMAF is a precursor of antibody drug conjugates (ADCs) with an enzymatically cleavable VAl-Cit site. The maleimide group is reactive with thiol bearing molecules. MMAF is a synthetic antineoplastic agent which may be employed as a cytotoxic payload. The Val-Cit will specifically be cleaved by Cathepsin B.
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