Val-Cit-PAB-MMAF is a cleavable ADC linker bound to Monomethyl auristatin F (MMAF). MMAF is an antitubulin agent that inhibits cell division by blocking the polymerization of tubulin. . The Val-Cit will specifically be cleaved by Cathepsin B. As this enzyme is only present in the lysosome, the ADC payload will be released only in the cell. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.
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