DBCO-PEG4-Val-Cit-PAB-MMAF is a cleavable ADC linker bound to Monomethyl auristatin F (MMAF). MMAF is an antitubulin agent that inhibits cell division by blocking the polymerization of tubulin. The Val-Cit will specifically be cleaved by Cathepsin B. The DBCO moiety serves as a click chemistry handle to react with azides. The PEG4 units strengthen the hydrophilicity of the molecule.
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