Ionizable Lipid

Ionizable Lipid


Ionizable Lipids is a class of lipid molecules that are neutral at physiological pH, but will be protonated at low pH, which makes them positively charged. The pH-sensitivity of ionizable lipids, such as such as ALC-0315 (Figure 1) is beneficial for mRNA delivery in vivo, because neutral lipids have less interactions with the anionic membranes of blood cells which improves the biocompatibility of lipid nanoparticles. Trapped in endosomes, in which the pH is lower than the pH in the extracellular environment, ionizable lipids are protonated and become positively charged, which may promote membrane destabilization and facilitate endosomal escape of the nanoparticles. Ionizable Lipids promote endosome escape and reduce toxicity of lipid nanoparticles (LNP).

Figure 1: Structure of ALC-0315

Catalog Product Name Structure M.W. Purity Pricing
Ionizable Lipid
BP-25497D-Lin-MC3-DMA642.198%Pricing
BP-25498((4-Hydroxybutyl)azanediyl)di(hexane-6,1-diyl) bis(2-hexyldecanoate)766.398%Pricing
BP-25499Heptadecan-9-yl 8-{(2-hydroxyethyl)[6-oxo-6-(undecyloxy)hexyl]amino}octanoate710.295%Pricing
BP-25707DODMA620.1Pricing
BP-25708DLin-KC2-DMA642.1Pricing